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John Edward Jones, PhD
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Children's National Medical Center
Faculty
Principal Investigator, Children's Research Institute (CRI), Center for Molecular Physiology Research (CMPR)
George Washington University
Research Associate Professor, Molecular Biology, Genetics
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Contact Information
Children's National Medical Center
Center for Molecular Physiology Research (CMPR)
111 Michigan Avenue, NW
Washington, DC 20010-2970
jnjones@cnmc.org
Education & Training
| Institution & Location |
Degree |
Year(s) |
Field of Study |
| University of Maryland, College Park, MD |
BS |
1977 |
Microbiology |
| Purdue University, West Lafayette, IN |
PhD |
1986 |
Molecular Genetics |
| Division of Cancer Prevention, NCI |
Senior Staff Fellow |
1991-1995 |
Biomarkers and Prevention Research Branch |
| NICHD, Lab of Developmental Pharmacology |
Staff Fellow |
1989-1991 |
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| NICHD, Lab of Developmental Pharmacology |
National Research Council Fellow |
1986-1989 |
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Research Interests
The central focus of Dr. Jones' research is the elucidation of the genetic causes of essential hypertension and salt-sensitivity to promote the development of diagnostic and therapeutic strategies. One of the goals of his research is the identification and characterization of novel interacting proteins of the key components in the metabolic pathways that control blood pressure. Dr. Jones has identified a member of the sorting nexin family, sorting nexin 5, (SNX5) as an interacting protein of the D1 dopamine receptor (D1R)—a protein that has been shown to play an integral role in the modulation of blood pressure. He is testing the hypothesis that SNX5 is important in the recycling of internalized D1R to the plasma membrane and the aberration of this regulatory function leads to hypertension.
Publications
View a partial list of publications for John Jones, PhD, through the National Library of Medicine's PubMed online database.
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